Version 5.4
Mus musculus Gene: Capn2
Summary
InnateDB Gene IDBG-207731.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capn2
Gene Name calpain 2
Synonyms AI326419; Capa-2; Capa2; m-calpain; m-calpin
Species Mus musculus
Ensembl Gene ENSMUSG00000026509
Encoded Proteins
IDBP-207733
calpain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162909:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5\' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:182467256-182517495
Strand Reverse strand
Band H5
Transcripts
ENSMUST00000068505 ENSMUSP00000068895
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008233 peptidase activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001824 blastocyst development
GO:0006508 proteolysis
GO:0007520 myoblast fusion
GO:0016540 protein autoprocessing
GO:0071230 cellular response to amino acid stimulus
Cellular Component
GO:0000785 chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0031143 pseudopodium
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162909
View Gene Order
ENSBTAG00000012778
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05010
Alzheimer's disease pathway
mmu04210
Apoptosis pathway
mmu04510
Focal adhesion pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04210
Apoptosis pathway
hsa05010
Alzheimer's disease pathway
hsa04510
Focal adhesion pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt O08529
TrEMBL Q8R486 Q920R9
UniProt Splice Variant
Entrez Gene 12334
UniGene Mm.19306 Mm.416255
RefSeq NM_009794
OMIM
CCDS CCDS35813
HPRD
IMGT
MGI ID MGI:88264
MGI Symbol Capn2
EMBL AB050199 AF015038 AF497625 BC054726 D38117 Y10139
GenPept AAB94029 AAH54726 AAM19226 BAA22964 BAB70477 CAA71227
RNA Seq Atlas 12334

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca