Mus musculus Gene: Pak7 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-207779.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | Pak7 | ||||||||||||||||||||
Gene Name | p21 protein (Cdc42/Rac)-activated kinase 7 | ||||||||||||||||||||
Synonyms | |||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||
Ensembl Gene | ENSMUSG00000039913 | ||||||||||||||||||||
Encoded Proteins |
p21 protein (Cdc42/Rac)-activated kinase 7
p21 protein (Cdc42/Rac)-activated kinase 7
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101349:
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 2:136081104-136387967 | ||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||
Band | F3 | ||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Signaling by Robo receptor pathway
Axon guidance pathway
Developmental Biology pathway
Activation of Rac pathway
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KEGG |
Axon guidance pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
T cell receptor signaling pathway pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
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INOH | |||||||||||||||||||||
PID NCI | |||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Activation of Rac pathway
Signaling by Robo receptor pathway
Developmental Biology pathway
Axon guidance pathway
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KEGG |
Regulation of actin cytoskeleton pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Axon guidance pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q8C015 | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 241656 | ||||||||||||||||||||
UniGene | Mm.131572 | ||||||||||||||||||||
RefSeq | NM_172858 XM_006499508 XM_006499509 XM_006499510 | ||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS16790 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
MGI ID | MGI:1920334 | ||||||||||||||||||||
MGI Symbol | Pak7 | ||||||||||||||||||||
EMBL | AK032593 AK163530 AY487425 | ||||||||||||||||||||
GenPept | AAR37415 BAC27939 BAE37385 | ||||||||||||||||||||
RNA Seq Atlas | 241656 | ||||||||||||||||||||