Version 5.4
Mus musculus Gene: Tnfrsf4
Summary
InnateDB Gene IDBG-208242.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnfrsf4
Gene Name tumor necrosis factor receptor superfamily, member 4
Synonyms ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L
Species Mus musculus
Ensembl Gene ENSMUSG00000029075
Encoded Proteins
IDBP-208244
tumor necrosis factor receptor superfamily, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186827:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:156013843-156016612
Strand Forward strand
Band E2
Transcripts
ENSMUST00000030952 ENSMUSP00000030952
ENSMUST00000143576
ENSMUST00000127377
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 19 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005031 tumor necrosis factor-activated receptor activity
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042098 T cell proliferation
GO:0042981 regulation of apoptotic process
GO:0045859 regulation of protein kinase activity
GO:0050710 negative regulation of cytokine secretion
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000186827
View Gene Order
ENSBTAG00000015635
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.13885
RefSeq NM_011659
OMIM
CCDS CCDS19055
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca