InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IGF2

Summary

InnateDB Gene

IDBG-20829.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2

Gene Name

insulin-like growth factor 2 (somatomedin A)

Synonyms

C11orf43; IGF-II; PP9974

Species

Homo sapiens

Ensembl Gene

ENSG00000167244

Encoded Proteins

IDBP-20831

insulin-like growth factor 2 (somatomedin A)

IDBP-20835

insulin-like growth factor 2 (somatomedin A)

IDBP-20839

insulin-like growth factor 2 (somatomedin A)

IDBP-20841

insulin-like growth factor 2 (somatomedin A)

IDBP-20845

insulin-like growth factor 2 (somatomedin A)

IDBP-361738

insulin-like growth factor 2 (somatomedin A)

IDBP-361744

insulin-like growth factor 2 (somatomedin A)

IDBP-361749

insulin-like growth factor 2 (somatomedin A)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5\' region overlaps the INS gene and the 3\' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:2129112-2149603

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000381406	ENSP00000370813
ENST00000381395	ENSP00000370802
ENST00000381392	ENSP00000370799
ENST00000381389	ENSP00000370796
ENST00000300632	ENSP00000300632
ENST00000416167	ENSP00000414497
ENST00000418738	ENSP00000402047
ENST00000434045	ENSP00000391826

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030546	receptor activator activity
GO:0043539	protein serine/threonine kinase activator activity

Biological Process

GO:0001501	skeletal system development
GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0002576	platelet degranulation
GO:0006006	glucose metabolic process
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007565	female pregnancy
GO:0007596	blood coagulation
GO:0007613	memory
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0009314	response to radiation
GO:0009887	organ morphogenesis
GO:0014070	response to organic cyclic compound
GO:0030168	platelet activation
GO:0031017	exocrine pancreas development
GO:0031667	response to nutrient levels
GO:0032355	response to estradiol
GO:0035094	response to nicotine
GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042060	wound healing
GO:0042104	positive regulation of activated T cell proliferation
GO:0042493	response to drug
GO:0043085	positive regulation of catalytic activity
GO:0043410	positive regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0045471	response to ethanol
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045840	positive regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051146	striated muscle cell differentiation
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0071260	cellular response to mechanical stimulus
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090031	positive regulation of steroid hormone biosynthetic process
GO:2000273	positive regulation of receptor activity
GO:2000467	positive regulation of glycogen (starch) synthase activity

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome