Version 5.4
Mus musculus Gene: Smurf1
Summary
InnateDB Gene IDBG-208404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smurf1
Gene Name SMAD specific E3 ubiquitin protein ligase 1
Synonyms 4930431E10Rik; mKIAA1625
Species Mus musculus
Ensembl Gene ENSMUSG00000038780
Encoded Proteins
IDBP-208406
SMAD specific E3 ubiquitin protein ligase 1
IDBP-208408
SMAD specific E3 ubiquitin protein ligase 1
IDBP-259747
SMAD specific E3 ubiquitin protein ligase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198742:
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:144876495-144965847
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000085684 ENSMUSP00000082827
ENSMUST00000100461 ENSMUSP00000098029
ENSMUST00000110677 ENSMUSP00000106305
ENSMUST00000126822
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 227 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 227 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006611 protein export from nucleus
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0016567 protein ubiquitination
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0032801 receptor catabolic process
GO:0034394 protein localization to cell surface
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198742
View Gene Order
ENSBTAG00000007118
Not yet available
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_215733
Downregulation of TGF-beta receptor signaling pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_220505
Signaling by BMP pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_230745
Immune System pathway
REACT_203510
TGF-beta receptor signaling activates SMADs pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_214043
PCP/CE pathway pathway
REACT_196549
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_229531
Adaptive Immune System pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_203973
Asymmetric localization of PCP proteins pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04144
Endocytosis pathway
INOH
INOH website
TGF-beta signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_12034
Signaling by BMP pathway
REACT_172581
PCP/CE pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04144
Endocytosis pathway
INOH
INOH website
TGF-beta signaling pathway
PID NCI
bmppathway
BMP receptor signaling
hdac_classi_pathway
Signaling events mediated by HDAC Class I
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL E9PYU8 Q8BSC0
UniProt Splice Variant
Entrez Gene 75788
UniGene Mm.27735 Mm.402254
RefSeq XM_006504882 XM_006504883 XM_006504884 XM_006504888 NM_001038627 NM_029438 XM_006504885 XM_006504886
OMIM
CCDS CCDS39380 CCDS39381
HPRD
IMGT
MGI ID MGI:1923038
MGI Symbol Smurf1
EMBL AC113295 AK034736
GenPept BAC28813
RNA Seq Atlas 75788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca