Version 5.4
Mus musculus Gene: Eef2k
Summary
InnateDB Gene IDBG-208568.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eef2k
Gene Name eukaryotic elongation factor-2 kinase
Synonyms C86191; eEF-2K
Species Mus musculus
Ensembl Gene ENSMUSG00000035064
Encoded Proteins
IDBP-208572
eukaryotic elongation factor-2 kinase
IDBP-268662
eukaryotic elongation factor-2 kinase
IDBP-268664
eukaryotic elongation factor-2 kinase
IDBP-268666
eukaryotic elongation factor-2 kinase
IDBP-541636
eukaryotic elongation factor-2 kinase
IDBP-531521
eukaryotic elongation factor-2 kinase
IDBP-539931
eukaryotic elongation factor-2 kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103319:
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:120842831-120907219
Strand Forward strand
Band F2
Transcripts
ENSMUST00000047875 ENSMUSP00000046595
ENSMUST00000106489 ENSMUSP00000102098
ENSMUST00000106488 ENSMUSP00000102097
ENSMUST00000106487 ENSMUSP00000102096
ENSMUST00000143279 ENSMUSP00000119567
ENSMUST00000143322 ENSMUSP00000115486
ENSMUST00000125828
ENSMUST00000146482 ENSMUSP00000114782
ENSMUST00000128813
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0004686 elongation factor-2 kinase activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008135 translation factor activity, nucleic acid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006414 translational elongation
GO:0006468 protein phosphorylation
GO:0031952 regulation of protein autophosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103319
View Gene Order
ENSBTAG00000017662
Not yet available
Pathways
NETPATH
REACTOME
REACT_240250
Signaling by Insulin receptor pathway
REACT_229737
S6K1 signalling pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_260675
S6K1-mediated signalling pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_240139
PI3K Cascade pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_231630
mTORC1-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6772
S6K1 signalling pathway
REACT_6754
S6K1-mediated signalling pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_456
PKB-mediated events pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
KEGG
INOH
PID NCI
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.25997 Mm.407798 Mm.470116
RefSeq NM_001267710 NM_001267711 NM_007908 XM_006507342 XM_006507343 XM_006507346
OMIM
CCDS CCDS21796
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca