Version 5.4
Mus musculus Gene: Scnn1g
Summary
InnateDB Gene IDBG-208747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scnn1g
Gene Name sodium channel, nonvoltage-gated 1 gamma
Synonyms [g]ENaC
Species Mus musculus
Ensembl Gene ENSMUSG00000000216
Encoded Proteins
IDBP-208749
sodium channel, nonvoltage-gated 1 gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166828:
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the gamma subunit, and mutations in this gene have been associated with Liddle syndrome. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:121734479-121768475
Strand Forward strand
Band F2
Transcripts
ENSMUST00000000221 ENSMUSP00000000221
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0050699 WW domain binding
Biological Process
GO:0006814 sodium ion transport
GO:0035725 sodium ion transmembrane transport
GO:0050891 multicellular organismal water homeostasis
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste
GO:0055078 sodium ion homeostasis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0034706 sodium channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166828
View Gene Order
ENSBTAG00000010163
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu04742
Taste transduction pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04742
Taste transduction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt Q9WU39
TrEMBL
UniProt Splice Variant
Entrez Gene 20278
UniGene Mm.35247
RefSeq NM_011326 XM_006507477
OMIM
CCDS CCDS21803
HPRD
IMGT
MGI ID MGI:104695
MGI Symbol Scnn1g
EMBL AF112187 BC021338
GenPept AAD21246 AAH21338
RNA Seq Atlas 20278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca