InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wasf3

Summary

InnateDB Gene

IDBG-208831.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wasf3

Gene Name

WAS protein family, member 3

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029636

Encoded Proteins

IDBP-208833

WAS protein family, member 3

IDBP-259917

WAS protein family, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132970:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:146384985-146472411

Strand

Forward strand

Band

Transcripts

ENSMUST00000016143	ENSMUSP00000016143
ENSMUST00000110600	ENSMUSP00000106230

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003779	actin binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0014003	oligodendrocyte development
GO:0030032	lamellipodium assembly
GO:0030036	actin cytoskeleton organization
GO:0031643	positive regulation of myelination

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0030027	lamellipodium

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000132970

View Gene Order

ENSBTAG00000014619

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04520

Adherens junction pathway

mmu04666

Fc gamma R-mediated phagocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160086

Regulation of actin dynamics for phagocytic cup formation pathway

REACT_12529

Signaling by VEGF pathway

REACT_6802

Innate Immune System pathway

REACT_111102

Signal Transduction pathway

REACT_6900

Immune System pathway

REACT_228166

VEGFA-VEGFR2 Pathway pathway

REACT_160123

Fcgamma receptor (FCGR) dependent phagocytosis pathway

KEGG

hsa04520

Adherens junction pathway

hsa04666

Fc gamma R-mediated phagocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

Q8VHI6

TrEMBL

D3YYA3

UniProt Splice Variant

Entrez Gene

245880

UniGene

Mm.472750

RefSeq

NM_145155 XM_006504833

OMIM

CCDS

CCDS19870

HPRD

IMGT

MGI ID

MGI:2658986

MGI Symbol

Wasf3

EMBL

AC093356 AC115019 AF454703 BC027038

GenPept

AAH27038 AAL51033

RNA Seq Atlas

245880