Version 5.4
Mus musculus Gene: Cst3
Summary
InnateDB Gene IDBG-209151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cst3
Gene Name cystatin C
Synonyms CysC
Species Mus musculus
Ensembl Gene ENSMUSG00000027447
Encoded Proteins
IDBP-209153
cystatin C
IDBP-532902
cystatin C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101439:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. [provided by RefSeq, Jul 2008]
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:148871722-148875692
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000028938 ENSMUSP00000028938
ENSMUST00000149691
ENSMUST00000144845 ENSMUSP00000117672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001775 cell activation
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0007431 salivary gland development
GO:0007566 embryo implantation
GO:0008284 positive regulation of cell proliferation
GO:0008584 male gonad development
GO:0009636 response to toxic substance
GO:0009743 response to carbohydrate
GO:0010035 response to inorganic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0014070 response to organic cyclic compound
GO:0031667 response to nutrient levels
GO:0032355 response to estradiol
GO:0034599 cellular response to oxidative stress
GO:0042493 response to drug
GO:0042747 circadian sleep/wake cycle, REM sleep
GO:0043067 regulation of programmed cell death
GO:0045740 positive regulation of DNA replication
GO:0048678 response to axon injury
GO:0060009 Sertoli cell development
GO:0060548 negative regulation of cell death
GO:0070301 cellular response to hydrogen peroxide
Cellular Component
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005771 multivesicular body
GO:0005783 endoplasmic reticulum
GO:0030424 axon
GO:0031965 nuclear membrane
GO:0031982 vesicle
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043292 contractile fiber
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101439
View Gene Order
ENSBTAG00000000598
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
KEGG
mmu04970
Salivary secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
REACT_206540
Amyloids pathway
REACT_207087
Disease pathway
KEGG
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt P21460
TrEMBL A2APX3 Q3U5K7
UniProt Splice Variant
Entrez Gene 13010
UniGene Mm.396690 Mm.469035 Mm.486105
RefSeq NM_009976
OMIM
CCDS CCDS16852
HPRD
IMGT
MGI ID MGI:102519
MGI Symbol Cst3
EMBL AF483486 AF483487 AK002438 AK013676 AK014368 AK131728 AK146333 AK151160 AK153533 AK161856 AK166430 AL844519 BC002072 M59470 U10098
GenPept AAA63298 AAB41056 AAH02072 AAL90760 AAL90761 BAB22101 BAB28949 BAB29303 BAE20785 BAE27088 BAE30165 BAE32071 BAE36608 BAE38771
RNA Seq Atlas 13010

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca