Version 5.4
Mus musculus Gene: Hmgb1
Summary
InnateDB Gene IDBG-209311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmgb1
Gene Name high mobility group box 1
Synonyms amphoterin; DEF; HMG-1; Hmg1; p30; SBP-1
Species Mus musculus
Ensembl Gene ENSMUSG00000066551
Encoded Proteins
IDBP-209313
high mobility group box 1
IDBP-260137
high mobility group box 1
IDBP-260136
high mobility group box 1
IDBP-531729
high mobility group box 1
IDBP-538016
high mobility group box 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21372296
Hmgb1 is an endogenous Tlr4 ligand in macrophages and its release in wounds initiates Tlr4-dependent responses that contribute to neovascularization.
PMID 21860212
Hmgb1 plays a key regulatory role in polymorphonuclear neutrophil (PMN) recruitment to inflammatory tissues. Low concentrations of Hmgb1 (50-100 ng/ml) reduce baseline PMN migration as well as formyl-methionyl-leucyl-phenylalanine- and Il8-induced PMN chemotaxis, whereas higher Hmgb1 concentrations (5000 ng/ml) have a chemoattractant effect on PMN through Il8 production . (Demonstrated in human)
PMID 21871094
Hmgb1 has a pathogenic role in arthritis, where in complex with lipopolysaccharide, Il1a or Il1b, Hmgb1 boosts the production of proinflammatory cytokines and Mmp3 as demonstrated in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients. (Demonstrated in human)
PMID 22396017
Nuclear Hmgb1 translocates to the cytoplasm in LPS-stimulated macrophages to potentiate inflammatory responses. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 19890330
[Homo sapiens] HMGB1 functions as universal sentinel for nucleic-acid-mediated innate immune responses.
PMID 19914413
[Homo sapiens] HMGB1 activates innate immunity mechanisms as a complex with DNA, lipids and/or pro-inflammatory cytokines.
PMID 20419158
[Homo sapiens] HMGB1 is an alarmin and a key mediator of natural killer (NK)-dendritic cell (DC) cross-talk and plays a pivotal role in the escape of Human Immunodeficiency Virus (HIV)-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk by upregulating c-FLIP and c-IAP2 expression.
PMID 21372296
[Homo sapiens] HMGB1 is an endogenous TLR4 ligand in macrophages and its release in wounds initiates TLR4-dependent responses that contribute to neovascularization. (Demonstrated in murine model)
PMID 21389264
[Homo sapiens] HMGB1 is found in high concentrations within neutrophil extracellular traps (NETs). HMGB1 is a neutrophil protein that facilitates the uptake and recognition of mammalian DNA by plasmacytoid dendritic cells, and may play a role in Systemic Lupus Erthermatosus autoimmunity.
PMID 21860212
[Homo sapiens] HMGB1 plays a key regulatory role in polymorphonuclear neutrophil (PMN) recruitment to inflammatory tissues. Low concentrations of HMGB1 (50-100 ng/ml) reduce baseline PMN migration as well as formyl-methionyl-leucyl-phenylalanine- and IL8-induced PMN chemotaxis, whereas higher HMGB1 concentrations (5000 ng/ml) have a chemoattractant effect on PMN through IL8 production.
PMID 21871094
[Homo sapiens] HMGB1 has a pathogenic role in arthritis, where in complex with lipopolysaccharide, IL1A or IL1B, HMGB1 boosts the production of proinflammatory cytokines and MMP3 as demonstrated in synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients.
PMID 22396017
[Homo sapiens] Nuclear HMGB1 translocates to the cytoplasm in LPS-stimulated macrophages to potentiate inflammatory responses. (Demonstrated in mice)
PMID 24257755
[Homo sapiens] Mast cell chymase CMA1 contributes to the control of inflammation by degrading the virulence factor Hsp70 of Trichinella spiralis, as well as several alarmins such as endogenous HSPA1A, BGN, and HMGB1..
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189403:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:149046702-149053513
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000085546 ENSMUSP00000082682
ENSMUST00000093196 ENSMUSP00000106131
ENSMUST00000110505 ENSMUSP00000106132
ENSMUST00000155086
ENSMUST00000139443
ENSMUST00000138553 ENSMUSP00000118733
ENSMUST00000133667
ENSMUST00000125605 ENSMUSP00000114515
ENSMUST00000123645
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008201 heparin binding
GO:0044822 poly(A) RNA binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002437 inflammatory response to antigenic stimulus
GO:0006288 base-excision repair, DNA ligation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006954 inflammatory response
GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0033151 V(D)J recombination
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2000426 negative regulation of apoptotic cell clearance
Cellular Component
GO:0000793 condensed chromosome
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000189403
View Gene Order
ENSBTAG00000018103
Not yet available
Pathways
NETPATH
REACTOME
REACT_202898
TRAF6 mediated NF-kB activation pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_229712
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_263004
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_258521
Apoptosis pathway
REACT_215449
Apoptosis induced DNA fragmentation pathway
REACT_245896
MyD88 cascade initiated on plasma membrane pathway
REACT_255939
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_215863
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_230745
Immune System pathway
REACT_260773
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_254406
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_205002
Activation of DNA fragmentation factor pathway
REACT_198647
Advanced glycosylation endproduct receptor signaling pathway
REACT_249409
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_202555
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_256727
MyD88 dependent cascade initiated on endosome pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_222971
RIP-mediated NFkB activation via ZBP1 pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_241786
MyD88-independent cascade pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_242921
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_230045
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_219800
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_207035
Apoptotic execution phase pathway
REACT_261340
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_13462
Activation of DNA fragmentation factor pathway
REACT_995
Apoptotic execution phase pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_1213
Apoptosis induced DNA fragmentation pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_578
Apoptosis pathway
REACT_163773
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_218237
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_210286
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_215546
Apoptosis induced DNA fragmentation pathway
REACT_224703
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_205566
Activated TLR4 signalling pathway
REACT_222278
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_224546
MyD88-independent cascade pathway
REACT_220974
Cytosolic sensors of pathogen-associated DNA pathway
REACT_217035
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_221101
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_227345
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_210224
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_218118
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_213138
Immune System pathway
REACT_226255
Activation of DNA fragmentation factor pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_207058
TRAF6 mediated NF-kB activation pathway
REACT_223848
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_225653
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_204725
Advanced glycosylation endproduct receptor signaling pathway
REACT_227007
Apoptotic execution phase pathway
REACT_218091
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_216676
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_219586
MyD88 dependent cascade initiated on endosome pathway
REACT_217214
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_216714
Innate Immune System pathway
REACT_209403
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_215391
RIP-mediated NFkB activation via ZBP1 pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_219454
Apoptosis pathway
REACT_217527
MyD88 cascade initiated on plasma membrane pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
integrin3_pathway
Beta3 integrin cell surface interactions
amb2_neutrophils_pathway
amb2 Integrin signaling
toll_endogenous_pathway
Endogenous TLR signaling
Cross-References
SwissProt P63158
TrEMBL D3YVC6 D3YZ18 Q58EV5 Q8BNM0 Q8C7C4
UniProt Splice Variant
Entrez Gene 619937
UniGene Mm.207047 Mm.402118 Mm.437213 Mm.455366 Mm.461535 Mm.470617
RefSeq NM_010439 XM_003945339 XM_006517801 XM_006543113 XM_006544655
OMIM
CCDS CCDS19883
HPRD
IMGT
MGI ID MGI:96113
MGI Symbol Hmgb1
EMBL AC158782 AK037928 AK050659 AK082902 AK084841 AK157846 BC006586 BC008565 BC083067 BC085090 BC091741 BC094030 BC110667 BC111468 L38477 U00431 X80457 Z11997
GenPept AAA20508 AAA57042 AAH06586 AAH08565 AAH83067 AAH85090 AAH91741 AAH94030 AAI10668 AAI11469 BAC29902 BAC34367 BAC38678 BAC39289 BAE34226 CAA56631 CAA78042
RNA Seq Atlas 100862258 102642363 15289 619937

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca