InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Brca2

Summary

InnateDB Gene

IDBG-209587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brca2

Gene Name

breast cancer 2

Synonyms

Fancd1; RAB163

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041147

Encoded Proteins

IDBP-209589

breast cancer 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139618:
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:150522630-150569746

Strand

Forward strand

Band

Transcripts

ENSMUST00000044620

ENSMUSP00000038576

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0010484	H3 histone acetyltransferase activity
GO:0010485	H4 histone acetyltransferase activity
GO:0043015	gamma-tubulin binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000910	cytokinesis
GO:0001556	oocyte maturation
GO:0001833	inner cell mass cell proliferation
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006355	regulation of transcription, DNA-templated
GO:0006974	cellular response to DNA damage stimulus
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007141	male meiosis I
GO:0007283	spermatogenesis
GO:0007420	brain development
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008585	female gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165	response to X-ray
GO:0010225	response to UV-C
GO:0010332	response to gamma radiation
GO:0030097	hemopoiesis
GO:0032465	regulation of cytokinesis
GO:0033600	negative regulation of mammary gland epithelial cell proliferation
GO:0042127	regulation of cell proliferation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043009	chordate embryonic development
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0048478	replication fork protection
GO:0051276	chromosome organization
GO:0051298	centrosome duplication

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0030141	secretory granule
GO:0033593	BRCA2-MAGE-D1 complex
GO:0043234	protein complex