InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Coro1a

Summary

InnateDB Gene

IDBG-209756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Coro1a

Gene Name

coronin, actin binding protein 1A

Synonyms

Clabp; Lmb3; p57; TACO

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030707

Encoded Proteins

IDBP-209758

coronin, actin binding protein 1A

IDBP-268914

coronin, actin binding protein 1A

IDBP-537571

coronin, actin binding protein 1A

IDBP-536543

coronin, actin binding protein 1A

IDBP-623324

coronin, actin binding protein 1A

IDBP-623329

coronin, actin binding protein 1A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the WD repeat coronin family. The encoded protein may bind actin and interact with microtubules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:126699773-126707787

Strand

Reverse strand

Band

Transcripts

ENSMUST00000032949	ENSMUSP00000032949
ENSMUST00000106364	ENSMUSP00000101972
ENSMUST00000133718
ENSMUST00000123511
ENSMUST00000140896
ENSMUST00000131415	ENSMUSP00000117931
ENSMUST00000135087	ENSMUSP00000115960
ENSMUST00000126193
ENSMUST00000173108	ENSMUSP00000134123
ENSMUST00000174579
ENSMUST00000173116	ENSMUSP00000133555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008092	cytoskeletal protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0006816	calcium ion transport
GO:0006909	phagocytosis
GO:0007015	actin filament organization
GO:0008064	regulation of actin polymerization or depolymerization
GO:0008360	regulation of cell shape
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0030335	positive regulation of cell migration
GO:0030595	leukocyte chemotaxis
GO:0030833	regulation of actin filament polymerization
GO:0031589	cell-substrate adhesion
GO:0032796	uropod organization
GO:0034097	response to cytokine
GO:0042102	positive regulation of T cell proliferation
GO:0043029	T cell homeostasis
GO:0048873	homeostasis of number of cells within a tissue
GO:0050870	positive regulation of T cell activation
GO:0050918	positive chemotaxis
GO:0051126	negative regulation of actin nucleation
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0001772	immunological synapse
GO:0001891	phagocytic cup
GO:0005737	cytoplasm
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030670	phagocytic vesicle membrane
GO:0030864	cortical actin cytoskeleton
GO:0031252	cell leading edge
GO:0043234	protein complex
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000102879

View Gene Order

ENSBTAG00000008631

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.290482

RefSeq

NM_009898 XM_006507284 XM_006507285 XM_006507286

OMIM

CCDS

CCDS21840

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas