InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Skap1

Summary

InnateDB Gene

IDBG-209950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Skap1

Gene Name

src family associated phosphoprotein 1

Synonyms

1700091G21Rik; Scap1; Skap-55

Species

Mus musculus

Ensembl Gene

ENSMUSG00000057058

Encoded Proteins

IDBP-209952

src family associated phosphoprotein 1

IDBP-209954

src family associated phosphoprotein 1

IDBP-209956

src family associated phosphoprotein 1

IDBP-209962

src family associated phosphoprotein 1

IDBP-266181

src family associated phosphoprotein 1

IDBP-266183

src family associated phosphoprotein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141293:
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:96464593-96759130

Strand

Forward strand

Band

Transcripts

ENSMUST00000103154	ENSMUSP00000099443
ENSMUST00000100521	ENSMUSP00000098090
ENSMUST00000071510	ENSMUSP00000071445
ENSMUST00000100519	ENSMUSP00000098088
ENSMUST00000107663	ENSMUSP00000103290
ENSMUST00000107662	ENSMUSP00000103289
ENSMUST00000136836
ENSMUST00000149988
ENSMUST00000127639
ENSMUST00000123814

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding

Biological Process

GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000141293

View Gene Order

ENSBTAG00000000641

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.403485

RefSeq

NM_001033186 NM_001177898 NM_001177899

OMIM

CCDS

CCDS25301 CCDS48891 CCDS48892

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas