InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sept1

Summary

InnateDB Gene

IDBG-210090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sept1

Gene Name

septin 1

Synonyms

Diff6; Pnutl3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000486

Encoded Proteins

IDBP-269021

septin 1

IDBP-269023

septin 1

IDBP-538130

septin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180096:
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer\'s disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:127214447-127218498

Strand

Reverse strand

Band

Transcripts

ENSMUST00000106314	ENSMUSP00000101921
ENSMUST00000106313	ENSMUSP00000101920
ENSMUST00000131208
ENSMUST00000152267
ENSMUST00000133913
ENSMUST00000133591
ENSMUST00000142356	ENSMUSP00000114468
ENSMUST00000138541
ENSMUST00000133733

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0007049	cell cycle
GO:0051301	cell division

Cellular Component

GO:0005815	microtubule organizing center
GO:0030496	midbody
GO:0031105	septin complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000180096

View Gene Order

ENSBTAG00000021219

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

hsa05100

Bacterial invasion of epithelial cells pathway

INOH

PID NCI

aurora_b_pathway

Aurora B signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.18

RefSeq

NM_017461 XM_006508030 XM_006508031

OMIM

CCDS

CCDS40141

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas