InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dnmt3b

Summary

InnateDB Gene

IDBG-210140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnmt3b

Gene Name

DNA methyltransferase 3B

Synonyms

MmuIIIB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027478

Encoded Proteins

IDBP-210142

DNA methyltransferase 3B

IDBP-210144

DNA methyltransferase 3B

IDBP-210146

DNA methyltransferase 3B

IDBP-210148

DNA methyltransferase 3B

IDBP-210150

DNA methyltransferase 3B

IDBP-210152

DNA methyltransferase 3B

IDBP-261662

DNA methyltransferase 3B

IDBP-261664

DNA methyltransferase 3B

IDBP-261666

DNA methyltransferase 3B

IDBP-261668

DNA methyltransferase 3B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:153649450-153687730

Strand

Forward strand

Band

Transcripts

ENSMUST00000103151	ENSMUSP00000099440
ENSMUST00000056495	ENSMUSP00000051830
ENSMUST00000081628	ENSMUSP00000080334
ENSMUST00000088976	ENSMUSP00000086370
ENSMUST00000103150	ENSMUSP00000099439
ENSMUST00000072997	ENSMUSP00000072761
ENSMUST00000109774	ENSMUSP00000105396
ENSMUST00000109773	ENSMUSP00000105395
ENSMUST00000109772	ENSMUSP00000105394
ENSMUST00000109771	ENSMUSP00000105393
ENSMUST00000132132
ENSMUST00000140811

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0045322	unmethylated CpG binding
GO:0046872	metal ion binding
GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006346	methylation-dependent chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0010212	response to ionizing radiation
GO:0010424	DNA methylation on cytosine within a CG sequence
GO:0010628	positive regulation of gene expression
GO:0031503	protein complex localization
GO:0042493	response to drug
GO:0043045	DNA methylation involved in embryo development
GO:0045666	positive regulation of neuron differentiation
GO:0045814	negative regulation of gene expression, epigenetic
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046498	S-adenosylhomocysteine metabolic process
GO:0046499	S-adenosylmethioninamine metabolic process
GO:0051571	positive regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0071230	cellular response to amino acid stimulus
GO:0090116	C-5 methylation of cytosine

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000088305

View Gene Order

ENSBTAG00000003901

Not yet available

Pathways

NETPATH

REACTOME

REACT_200794

Mus musculus biological processes pathway

REACT_200667

NoRC negatively regulates rRNA expression pathway

REACT_222475

PRC2 methylates histones and DNA pathway

REACT_214440

NoRC negatively regulates rRNA expression pathway

REACT_205737

Epigenetic regulation of gene expression pathway

REACT_233572

Gene Expression pathway

REACT_268475

DNA methylation pathway

REACT_207809

Negative epigenetic regulation of rRNA expression pathway

KEGG

mmu00270

Cysteine and methionine metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_200808

PRC2 methylates histones and DNA pathway

REACT_200857

Epigenetic regulation of gene expression pathway

REACT_200856

NoRC negatively regulates rRNA expression pathway

REACT_267652

DNA methylation pathway

REACT_71

Gene Expression pathway

REACT_200834

Negative epigenetic regulation of rRNA expression pathway

KEGG

hsa00270

Cysteine and methionine metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.398574 Mm.89772

RefSeq

NM_001003960 NM_001003961 NM_001003963 NM_001122997 NM_001271744 NM_001271745 NM_001271746 NM_001271747 NM_010068 XM_006498682 XM_006498683 XM_006498684 XM_006498685 XM_006498686 XM_006498687 XM_006498688 XM_006498689

OMIM

CCDS

CCDS16913 CCDS16914 CCDS16915 CCDS16916 CCDS50759

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas