InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Phkg2

Summary

InnateDB Gene

IDBG-210288.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phkg2

Gene Name

phosphorylase kinase, gamma 2 (testis)

Synonyms

1500017I02Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030815

Encoded Proteins

IDBP-210290

phosphorylase kinase, gamma 2 (testis)

IDBP-400195

phosphorylase kinase, gamma 2 (testis)

IDBP-539560

phosphorylase kinase, gamma 2 (testis)

IDBP-539714

phosphorylase kinase, gamma 2 (testis)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156873:
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:127573340-127583305

Strand

Forward strand

Band

Transcripts

ENSMUST00000033086	ENSMUSP00000033086
ENSMUST00000121004	ENSMUSP00000113533
ENSMUST00000129457
ENSMUST00000151908
ENSMUST00000146383	ENSMUSP00000115593
ENSMUST00000154891	ENSMUSP00000116860
ENSMUST00000138158
ENSMUST00000133621
ENSMUST00000149853

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004689	phosphorylase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups