Mus musculus Gene: Hsd3b7 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-210381.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Hsd3b7 | ||||||||||||||||||||||
Gene Name | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | ||||||||||||||||||||||
Synonyms | AI195443; BB098564 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000042289 | ||||||||||||||||||||||
Encoded Proteins |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099377:
This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 7:127785608-127803802 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | F3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Synthesis of bile acids and bile salts pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Bile acid and bile salt metabolism pathway
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KEGG |
Primary bile acid biosynthesis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Synthesis of bile acids and bile salts pathway
Metabolism of lipids and lipoproteins pathway
Bile acid and bile salt metabolism pathway
Metabolism pathway
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KEGG |
Primary bile acid biosynthesis pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D3YU71 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 101502 | ||||||||||||||||||||||
UniGene | Mm.486340 | ||||||||||||||||||||||
RefSeq | NM_001040684 NM_133943 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS40145 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:2141879 | ||||||||||||||||||||||
MGI Symbol | Hsd3b7 | ||||||||||||||||||||||
EMBL | AC149222 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 101502 | ||||||||||||||||||||||