Version 5.4
Homo sapiens Gene: USP6
Summary
InnateDB Gene IDBG-21050.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP6
Gene Name ubiquitin specific peptidase 6 (Tre-2 oncogene)
Synonyms HRP1; Tre-2; TRE17; TRE2; TRESMCR; USP6-short
Species Homo sapiens
Ensembl Gene ENSG00000129204
Encoded Proteins
IDBP-21054
ubiquitin specific peptidase 6 (Tre-2 oncogene)
IDBP-760570
IDBP-764266
IDBP-760998
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:5116438-5175034
Strand Forward strand
Band p13.2
Transcripts
ENST00000250066 ENSP00000250066
ENST00000357482
ENST00000572949 ENSP00000461581
ENST00000575709 ENSP00000461817
ENST00000572429
ENST00000574788 ENSP00000460380
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004197 cysteine-type endopeptidase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
GO:0060627 regulation of vesicle-mediated transport
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0055037 recycling endosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.448851 Hs.603697
RefSeq NM_004505 XM_005256845
HUGO
OMIM
CCDS CCDS11069
HPRD 06827
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca