InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ahcy

Summary

InnateDB Gene

IDBG-210511.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ahcy

Gene Name

S-adenosylhomocysteine hydrolase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027597

Encoded Proteins

IDBP-210513

S-adenosylhomocysteine hydrolase

IDBP-539098

S-adenosylhomocysteine hydrolase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101444:
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:155059310-155074497

Strand

Reverse strand

Band

Transcripts

ENSMUST00000054607	ENSMUSP00000061851
ENSMUST00000137242	ENSMUSP00000116774
ENSMUST00000146367

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004013	adenosylhomocysteinase activity
GO:0004455	ketol-acid reductoisomerase activity
GO:0005515	protein binding
GO:0051287	NAD binding