InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itgam

Summary

InnateDB Gene

IDBG-210531.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgam

Gene Name

integrin alpha M

Synonyms

Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030786

Encoded Proteins

IDBP-210533

integrin alpha M

IDBP-210535

integrin alpha M

IDBP-269167

integrin alpha M

IDBP-269169

integrin alpha M

IDBP-400175

integrin alpha M

IDBP-400176

integrin alpha M

IDBP-540682

integrin alpha M

IDBP-533459

integrin alpha M

IDBP-531632

integrin alpha M

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20639876

Itgam (Cd11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the Myd88 and Ticam1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.

PMID 21245270

Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.

PMID 24423728

Itgam (Cd11b) fine tunes the balance between adaptive and innate immune responses initiated by LPS by modulating the trafficking and signalling functions of Tlr4 in a cell-type-specific manner.

PMID 25538234

Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.

InnateDB Annotation from Orthologs

Summary

PMID 20639876

[Homo sapiens] ITGAM (CD11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the MYD88 and TICAM1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.

PMID 21245270

[Homo sapiens] ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169896:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (\'Mac-1\'), or inactivated-C3b (iC3b) receptor 3 (\'CR3\'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:128062640-128128160

Strand

Forward strand

Band

Transcripts

ENSMUST00000098015	ENSMUSP00000095625
ENSMUST00000064821	ENSMUSP00000068468
ENSMUST00000106242	ENSMUSP00000101849
ENSMUST00000106240	ENSMUSP00000101847
ENSMUST00000120355	ENSMUSP00000113957
ENSMUST00000119696	ENSMUSP00000113412
ENSMUST00000156593	ENSMUSP00000121676
ENSMUST00000126475	ENSMUSP00000117293
ENSMUST00000134694	ENSMUSP00000117120

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0001948	glycoprotein binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002523	leukocyte migration involved in inflammatory response
GO:0006412	translation
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0014005	microglia development
GO:0016337	single organismal cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0050798	activated T cell proliferation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005840	ribosome
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome