Version 5.4
Mus musculus Gene: Pnmt
Summary
InnateDB Gene IDBG-210576.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnmt
Gene Name phenylethanolamine-N-methyltransferase
Synonyms Pent
Species Mus musculus
Ensembl Gene ENSMUSG00000038216
Encoded Proteins
IDBP-210578
phenylethanolamine-N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141744:
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:98386450-98388181
Strand Forward strand
Band D
Transcripts
ENSMUST00000041301 ENSMUSP00000035549
ENSMUST00000124527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141744
View Gene Order
ENSBTAG00000011731
Not yet available
Pathways
NETPATH
REACTOME
REACT_217777
Catecholamine biosynthesis pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_215158
Amine-derived hormones pathway
KEGG
mmu00350
Tyrosine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15551
Catecholamine biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00350
Tyrosine metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt P40935
TrEMBL Q0VB50
UniProt Splice Variant
Entrez Gene 18948
UniGene Mm.57030
RefSeq NM_008890
OMIM
CCDS CCDS25347
HPRD
IMGT
MGI ID MGI:97724
MGI Symbol Pnmt
EMBL BC119079 BC120789 CH466556 L12687
GenPept AAA68934 AAI19080 AAI20790 EDL16137
RNA Seq Atlas 18948

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca