InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grb7

Summary

InnateDB Gene

IDBG-210622.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grb7

Gene Name

growth factor receptor bound protein 7

Synonyms

mKIAA4028

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019312

Encoded Proteins

IDBP-210624

growth factor receptor bound protein 7

IDBP-536358

growth factor receptor bound protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141738:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:98446394-98455373

Strand

Forward strand

Band

Transcripts

ENSMUST00000019456	ENSMUSP00000019456
ENSMUST00000132771	ENSMUSP00000119926
ENSMUST00000127914
ENSMUST00000156328
ENSMUST00000133419
ENSMUST00000129034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0035091	phosphatidylinositol binding
GO:0042802	identical protein binding

Biological Process

GO:0007165	signal transduction
GO:0009967	positive regulation of signal transduction
GO:0017148	negative regulation of translation
GO:0030335	positive regulation of cell migration
GO:0034063	stress granule assembly