InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Src

Summary

InnateDB Gene

IDBG-211273.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Src

Gene Name

Rous sarcoma oncogene

Synonyms

AW259666; pp60c-src

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027646

Encoded Proteins

IDBP-211275

Rous sarcoma oncogene

IDBP-211277

Rous sarcoma oncogene

IDBP-262190

Rous sarcoma oncogene

IDBP-262192

Rous sarcoma oncogene

IDBP-262194

Rous sarcoma oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19667404

[Homo sapiens] SRC and STAT3 play a role in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197122:
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:157418444-157471862

Strand

Forward strand

Band

Transcripts

ENSMUST00000092576	ENSMUSP00000090237
ENSMUST00000029175	ENSMUSP00000029175
ENSMUST00000109533	ENSMUSP00000105159
ENSMUST00000109531	ENSMUSP00000105157
ENSMUST00000109529	ENSMUSP00000105155
ENSMUST00000145715
ENSMUST00000129770
ENSMUST00000133900

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 348 interaction(s) predicted by orthology.

Experimentally validated
Total	119 [view]
Protein-Protein	117 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	348 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005080	protein kinase C binding
GO:0005102	receptor binding
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0020037	heme binding
GO:0030331	estrogen receptor binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0044325	ion channel binding
GO:0046875	ephrin receptor binding
GO:0050839	cell adhesion molecule binding
GO:0051219	phosphoprotein binding
GO:0070851	growth factor receptor binding

Biological Process

GO:0002376	immune system process
GO:0006468	protein phosphorylation
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008283	cell proliferation
GO:0009612	response to mechanical stimulus
GO:0009615	response to virus
GO:0010447	response to acidity
GO:0010628	positive regulation of gene expression
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0010907	positive regulation of glucose metabolic process
GO:0014911	positive regulation of smooth muscle cell migration
GO:0016337	single organismal cell-cell adhesion
GO:0016477	cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030900	forebrain development
GO:0031667	response to nutrient levels
GO:0031954	positive regulation of protein autophosphorylation
GO:0032148	activation of protein kinase B activity
GO:0032463	negative regulation of protein homooligomerization
GO:0032869	cellular response to insulin stimulus
GO:0033146	regulation of intracellular estrogen receptor signaling pathway
GO:0034332	adherens junction organization
GO:0035556	intracellular signal transduction
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043393	regulation of protein binding
GO:0043406	positive regulation of MAP kinase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045056	transcytosis
GO:0045453	bone resorption
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045785	positive regulation of cell adhesion
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0046777	protein autophosphorylation
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048477	oogenesis
GO:0050715	positive regulation of cytokine secretion
GO:0050847	progesterone receptor signaling pathway
GO:0051222	positive regulation of protein transport
GO:0051385	response to mineralocorticoid
GO:0051602	response to electrical stimulus
GO:0051895	negative regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0051902	negative regulation of mitochondrial depolarization
GO:0060065	uterus development
GO:0060444	branching involved in mammary gland duct morphogenesis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070542	response to fatty acid
GO:0070555	response to interleukin-1
GO:0071222	cellular response to lipopolysaccharide
GO:0071393	cellular response to progesterone stimulus
GO:0071398	cellular response to fatty acid
GO:0071456	cellular response to hypoxia
GO:0071803	positive regulation of podosome assembly
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1902533	positive regulation of intracellular signal transduction
GO:2000573	positive regulation of DNA biosynthetic process
GO:2000811	negative regulation of anoikis
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0014069	postsynaptic density
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000197122

View Gene Order

ENSBTAG00000008938

Not yet available

Pathways

NETPATH

REACTOME

REACT_239142

Innate Immune System pathway

REACT_245546

GP1b-IX-V activation signalling pathway

REACT_224389

Gap junction trafficking and regulation pathway

REACT_188191

Signaling by ERBB2 pathway

REACT_189085

Disease pathway

REACT_224553

Hemostasis pathway

REACT_257923

Recycling pathway of L1 pathway

REACT_209837

Membrane Trafficking pathway

REACT_229826

Netrin-1 signaling pathway

REACT_227951

Signaling by VEGF pathway

REACT_227425

Regulation of KIT signaling pathway

REACT_188177

Signaling by FGFR in disease pathway

REACT_188578

Signaling by SCF-KIT pathway

REACT_243939

EPHA-mediated growth cone collapse pathway

REACT_224600

c-src mediated regulation of Cx43 function and closure of gap junctions pathway

REACT_245086

VEGFR2 mediated cell proliferation pathway

REACT_230745

Immune System pathway

REACT_224879

Platelet activation, signaling and aggregation pathway

REACT_230639

Downstream signal transduction pathway

REACT_198525

Negative regulation of FGFR signaling pathway

REACT_198526

Spry regulation of FGF signaling pathway

REACT_243212

DSCAM interactions pathway

REACT_248291

DCC mediated attractive signaling pathway

REACT_239722

Signalling to RAS pathway

REACT_196487

FCGR activation pathway

REACT_243590

EPH-ephrin mediated repulsion of cells pathway

REACT_242976

Signaling by EGFR pathway

REACT_258158

EPH-Ephrin signaling pathway

REACT_204081

CD28 co-stimulation pathway

REACT_225477

Costimulation by the CD28 family pathway

REACT_207601

p38MAPK events pathway

REACT_257656

EPHB-mediated forward signaling pathway

REACT_257088

VEGFA-VEGFR2 Pathway pathway

REACT_261444

Axon guidance pathway

REACT_231290

Signalling to ERKs pathway

REACT_238268

GRB2:SOS provides linkage to MAPK signaling for Integrins pathway

REACT_220322

Thrombin signalling through proteinase activated receptors (PARs) pathway

REACT_259068

ADP signalling through P2Y purinoceptor 1 pathway

REACT_209368

Fcgamma receptor (FCGR) dependent phagocytosis pathway

REACT_261568

CTLA4 inhibitory signaling pathway

REACT_219680

L1CAM interactions pathway

REACT_248921

Signalling by NGF pathway

REACT_229531

Adaptive Immune System pathway

REACT_263353

Signaling by PDGF pathway

REACT_188576

Developmental Biology pathway

REACT_206286

GAB1 signalosome pathway

REACT_241951

Ephrin signaling pathway

REACT_240371

p130Cas linkage to MAPK signaling for integrins pathway

REACT_237883

NGF signalling via TRKA from the plasma membrane pathway

REACT_188257

Signal Transduction pathway

REACT_246176

Integrin alphaIIb beta3 signaling pathway

REACT_242456

Signaling by FGFR pathway

REACT_249309

Platelet Aggregation (Plug Formation) pathway

REACT_253341

Netrin mediated repulsion signals pathway

REACT_251507

Signal amplification pathway

REACT_223082

Cell-Cell communication pathway

REACT_214111

Regulation of gap junction activity pathway

REACT_188180

Signaling by EGFR in Cancer pathway

REACT_237796

NCAM signaling for neurite out-growth pathway

KEGG

mmu04530

Tight junction pathway

mmu04012

ErbB signaling pathway pathway

mmu04370

VEGF signaling pathway pathway

mmu04540

Gap junction pathway

mmu04912

GnRH signaling pathway pathway

mmu04810

Regulation of actin cytoskeleton pathway

mmu04520

Adherens junction pathway

mmu04510

Focal adhesion pathway

mmu04062

Chemokine signaling pathway pathway

mmu04144

Endocytosis pathway

mmu05100

Bacterial invasion of epithelial cells pathway

INOH