Version 5.4
Mus musculus Gene: Ebf3
Summary
InnateDB Gene IDBG-211411.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ebf3
Gene Name early B cell factor 3
Synonyms 3110018A08Rik; mKIAA4201; O/E-2
Species Mus musculus
Ensembl Gene ENSMUSG00000010476
Encoded Proteins
IDBP-211413
early B-cell factor 3
IDBP-269433
early B-cell factor 3
IDBP-625042
early B-cell factor 3
IDBP-625045
early B-cell factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108001:
This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:137193673-137314445
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000033378 ENSMUSP00000033378
ENSMUST00000106118 ENSMUSP00000101724
ENSMUST00000168203 ENSMUSP00000130334
ENSMUST00000169486 ENSMUSP00000132563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000108001
View Gene Order
Cross-References
SwissProt O08791
TrEMBL Q3UUB6 Q5DTH8 Q6NXL3 Q6P3E8
UniProt Splice Variant
Entrez Gene 13593
UniGene Mm.258708
RefSeq NM_001113414 NM_001113415 NM_010096 XM_006507339
OMIM
CCDS CCDS21946 CCDS52422 CCDS52423
HPRD
IMGT
MGI ID MGI:894289
MGI Symbol Ebf3
EMBL AC135639 AK138602 AK220542 BC064016 BC067018 U82442 U92702 U92704
GenPept AAB58322 AAB58324 AAC64323 AAH64016 AAH67018 BAD90316 BAE23711
RNA Seq Atlas 13593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca