InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp6v0a1

Summary

InnateDB Gene

IDBG-211715.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp6v0a1

Gene Name

ATPase, H+ transporting, lysosomal V0 subunit A1

Synonyms

AA959968; ATP6a1; Atp6n1; Atp6n1a; Atpv0a1; Vpp-1; Vpp1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019302

Encoded Proteins

IDBP-211717

ATPase, H+ transporting, lysosomal V0 subunit A1

IDBP-211719

ATPase, H+ transporting, lysosomal V0 subunit A1

IDBP-211721

ATPase, H+ transporting, lysosomal V0 subunit A1

IDBP-539943

ATPase, H+ transporting, lysosomal V0 subunit A1

IDBP-627105

ATPase, H+ transporting, lysosomal V0 subunit A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000033627:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c\', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101009452-101063719

Strand

Forward strand

Band

Transcripts

ENSMUST00000103110	ENSMUSP00000099399
ENSMUST00000044721	ENSMUSP00000044838
ENSMUST00000092663	ENSMUSP00000090333
ENSMUST00000154896
ENSMUST00000151554
ENSMUST00000139619	ENSMUSP00000121247
ENSMUST00000134919
ENSMUST00000139857
ENSMUST00000127810
ENSMUST00000168757	ENSMUSP00000131848

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0051117	ATPase binding

Biological Process

GO:0015991

ATP hydrolysis coupled proton transport

Cellular Component

GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0033179	proton-transporting V-type ATPase, V0 domain
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome