InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Srsf6

Summary

InnateDB Gene

IDBG-211780.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srsf6

Gene Name

serine/arginine-rich splicing factor 6

Synonyms

1210001E11Rik; AI314910; AW146126; Sfrs6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000016921

Encoded Proteins

IDBP-532693

serine/arginine-rich splicing factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:162931528-162937121

Strand

Forward strand

Band

Transcripts

ENSMUST00000017065
ENSMUST00000130411	ENSMUSP00000119065
ENSMUST00000126163

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	5 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006376	mRNA splice site selection
GO:0010837	regulation of keratinocyte proliferation
GO:0045617	negative regulation of keratinocyte differentiation
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060548	negative regulation of cell death
GO:0061041	regulation of wound healing