InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cyp2e1

Summary

InnateDB Gene

IDBG-211819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp2e1

Gene Name

cytochrome P450, family 2, subfamily e, polypeptide 1

Synonyms

Cyp2e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025479

Encoded Proteins

IDBP-211821

cytochrome P450, family 2, subfamily e, polypeptide 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130649:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:140763739-140774975

Strand

Forward strand

Band

Transcripts

ENSMUST00000026552

ENSMUSP00000026552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016491	oxidoreductase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0019899	enzyme binding
GO:0020037	heme binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0008202	steroid metabolic process
GO:0010193	response to ozone
GO:0010243	response to organonitrogen compound
GO:0016098	monoterpenoid metabolic process
GO:0017144	drug metabolic process
GO:0042493	response to drug
GO:0045471	response to ethanol
GO:0046483	heterocycle metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0031227	intrinsic component of endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle