Version 5.4
Mus musculus Gene: Psmc3ip
Summary
InnateDB Gene IDBG-211834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmc3ip
Gene Name proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
Synonyms C79099; GT198; HOP2; Tbpip
Species Mus musculus
Ensembl Gene ENSMUSG00000019303
Encoded Proteins
IDBP-211836
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
IDBP-532293
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131470:
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101091823-101095436
Strand Reverse strand
Band D
Transcripts
ENSMUST00000019447 ENSMUSP00000019447
ENSMUST00000126386
ENSMUST00000134520
ENSMUST00000142545 ENSMUSP00000117100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006310 DNA recombination
GO:0007126 meiotic nuclear division
GO:0045892 negative regulation of transcription, DNA-templated
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131470
View Gene Order
ENSBTAG00000020907
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_008949 XM_006532523 XM_006532524
OMIM
CCDS CCDS25448
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca