Version 5.4
Mus musculus Gene: Ezh1
Summary
InnateDB Gene IDBG-211954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ezh1
Gene Name enhancer of zeste homolog 1 (Drosophila)
Synonyms ENX-2
Species Mus musculus
Ensembl Gene ENSMUSG00000006920
Encoded Proteins
IDBP-211958
enhancer of zeste homolog 1 (Drosophila)
IDBP-266994
enhancer of zeste homolog 1 (Drosophila)
IDBP-266996
enhancer of zeste homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Polycomb-group (PcG) family. The encoded protein is interchangeable with the related Enhancer of zeste 2 (Ezh2) protein as a core component of the polycomb repressive complex 2 (PRC2), which methylates histone H3 at lysine 27 and results in the transcriptional repression of affected target genes. This complex is involved in carrying out cell-fate decisions during embryonic stem cell differentiation. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101191115-101226463
Strand Reverse strand
Band D
Transcripts
ENSMUST00000100417 ENSMUSP00000097984
ENSMUST00000107285 ENSMUSP00000102906
ENSMUST00000107284 ENSMUSP00000102905
ENSMUST00000134622
ENSMUST00000138835
ENSMUST00000146884
ENSMUST00000128974
ENSMUST00000154211
ENSMUST00000151291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046976 histone methyltransferase activity (H3-K27 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0070734 histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0035098 ESC/E(Z) complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000108799
View Gene Order
ENSBTAG00000021918
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.5027
RefSeq NM_007970 XM_006532177 XM_006532178
OMIM
CCDS CCDS36335
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca