InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wnk4

Summary

InnateDB Gene

IDBG-211994.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnk4

Gene Name

WNK lysine deficient protein kinase 4

Synonyms

2010002J11Rik; Pha2b; Prkwnk4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035112

Encoded Proteins

IDBP-212002

WNK lysine deficient protein kinase 4

IDBP-627673

WNK lysine deficient protein kinase 4

IDBP-627670

WNK lysine deficient protein kinase 4

IDBP-627674

WNK lysine deficient protein kinase 4

IDBP-627675

WNK lysine deficient protein kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126562:
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:101260567-101277409

Strand

Forward strand

Band

Transcripts

ENSMUST00000103108	ENSMUSP00000099397
ENSMUST00000147741	ENSMUSP00000131298
ENSMUST00000139487	ENSMUSP00000129666
ENSMUST00000170056	ENSMUSP00000132123
ENSMUST00000170372	ENSMUSP00000131954

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019869	chloride channel inhibitor activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006811	ion transport
GO:0006821	chloride transport
GO:0008104	protein localization
GO:0030644	cellular chloride ion homeostasis
GO:0035556	intracellular signal transduction
GO:0050794	regulation of cellular process
GO:0050801	ion homeostasis
GO:0070294	renal sodium ion absorption
GO:0072156	distal tubule morphogenesis
GO:0090188	negative regulation of pancreatic juice secretion

Cellular Component

GO:0005737	cytoplasm
GO:0005923	tight junction

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000126562

View Gene Order

ENSBTAG00000019907

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9PZ38

UniProt Splice Variant

Entrez Gene

69847

UniGene

Mm.23656

RefSeq

NM_175638 XM_006534136 XM_006534137 XM_006534138

OMIM

CCDS

CCDS25459

HPRD

IMGT

MGI ID

MGI:1917097

MGI Symbol

Wnk4

EMBL

AL590969

GenPept

RNA Seq Atlas

69847