InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stk4

Summary

InnateDB Gene

IDBG-212019.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk4

Gene Name

serine/threonine kinase 4

Synonyms

AI447339; AU020804; Kas-2; Mst1; Ysk3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018209

Encoded Proteins

IDBP-212021

serine/threonine kinase 4

IDBP-212023

serine/threonine kinase 4

IDBP-540217

serine/threonine kinase 4

IDBP-537072

serine/threonine kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101109:
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it\'s possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:164070322-164155524

Strand

Forward strand

Band

Transcripts

ENSMUST00000018353	ENSMUSP00000018353
ENSMUST00000088291	ENSMUSP00000085629
ENSMUST00000134078	ENSMUSP00000122440
ENSMUST00000153319
ENSMUST00000137866	ENSMUSP00000116745

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043539	protein serine/threonine kinase activator activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001569	patterning of blood vessels
GO:0001841	neural tube formation
GO:0003157	endocardium development
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007417	central nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0018105	peptidyl-serine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0030216	keratinocyte differentiation
GO:0035329	hippo signaling
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0046621	negative regulation of organ growth
GO:0046777	protein autophosphorylation
GO:0060215	primitive hemopoiesis
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0097284	hepatocyte apoptotic process
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000101109

View Gene Order

ENSBTAG00000003257

Not yet available

Pathways

NETPATH

REACTOME

REACT_196537

Signaling by Hippo pathway

REACT_188257

Signal Transduction pathway

KEGG

mmu04010

MAPK signaling pathway pathway

mmu05223

Non-small cell lung cancer pathway

mmu05200

Pathways in cancer pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

REACT_118607

Signaling by Hippo pathway

REACT_111102

Signal Transduction pathway

REACT_214353

Signal Transduction pathway

REACT_217897

Signaling by Hippo pathway

KEGG

hsa05223

Non-small cell lung cancer pathway

hsa04010

MAPK signaling pathway pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

Cross-References

SwissProt

Q9JI11

TrEMBL

A2A5M9 Q8CDG4

UniProt Splice Variant

Entrez Gene

58231

UniGene

Mm.234472 Mm.490677

RefSeq

NM_021420

OMIM

CCDS

CCDS17021

HPRD

IMGT

MGI ID

MGI:1929004

MGI Symbol

Stk4

EMBL

AF271360 AK028838 AK030098 AL591512 AL591542 BC054521

GenPept

AAF75789 AAH54521 BAC26147 BAC26783

RNA Seq Atlas

58231