Version 5.4
Mus musculus Gene: Pigt
Summary
InnateDB Gene IDBG-212207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pigt
Gene Name phosphatidylinositol glycan anchor biosynthesis, class T
Synonyms 2510012P17Rik; 4930534E15Rik; CGI-06; NDAP; Ndap7
Species Mus musculus
Ensembl Gene ENSMUSG00000017721
Encoded Proteins
IDBP-212209
phosphatidylinositol glycan anchor biosynthesis, class T
IDBP-401787
phosphatidylinositol glycan anchor biosynthesis, class T
IDBP-533628
phosphatidylinositol glycan anchor biosynthesis, class T
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124155:
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This protein is an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:164497520-164508301
Strand Forward strand
Band H3
Transcripts
ENSMUST00000103101 ENSMUSP00000099390
ENSMUST00000117066 ENSMUSP00000112577
ENSMUST00000138038
ENSMUST00000152522 ENSMUSP00000115362
ENSMUST00000131976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
Biological Process
GO:0016255 attachment of GPI anchor to protein
GO:0030182 neuron differentiation
GO:0051402 neuron apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0042765 GPI-anchor transamidase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124155
View Gene Order
ENSBTAG00000016122
Not yet available
Pathways
NETPATH
REACTOME
REACT_244576
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_236590
Attachment of GPI anchor to uPAR pathway
KEGG
mmu00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1830
Attachment of GPI anchor to uPAR pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28228
RefSeq NM_133779
OMIM
CCDS CCDS17038
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca