Version 5.4
Mus musculus Gene: Ctsa
Summary
InnateDB Gene IDBG-212379.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctsa
Gene Name cathepsin A
Synonyms AU019505; PPCA; Ppgb
Species Mus musculus
Ensembl Gene ENSMUSG00000017760
Encoded Proteins
IDBP-212381
cathepsin A
IDBP-212383
cathepsin A
IDBP-212385
cathepsin A
IDBP-541448
cathepsin A
IDBP-539716
cathepsin A
IDBP-537459
cathepsin A
IDBP-531563
cathepsin A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a glycoprotein with deamidase, esterase and carboxypeptidase activities. The encoded protein associates with and provides a protective function to the lysosomal enzymes beta-galactosidase and neuraminidase. Deficiency of the related gene in humans results in galactosialidosis. The proprotein is processed into two shorter chains. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:164832873-164841032
Strand Forward strand
Band H3
Transcripts
ENSMUST00000017904 ENSMUSP00000017904
ENSMUST00000103093 ENSMUSP00000099382
ENSMUST00000103092 ENSMUSP00000099381
ENSMUST00000133502
ENSMUST00000151493 ENSMUSP00000116210
ENSMUST00000127650 ENSMUSP00000115514
ENSMUST00000147883
ENSMUST00000146525
ENSMUST00000143780 ENSMUSP00000123413
ENSMUST00000155061
ENSMUST00000152721 ENSMUSP00000119814
ENSMUST00000133077
ENSMUST00000130959
ENSMUST00000128596
ENSMUST00000143293
ENSMUST00000144580
ENSMUST00000140213
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004185 serine-type carboxypeptidase activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000064601
View Gene Order
ENSBTAG00000027337
Not yet available
Pathways
NETPATH
REACTOME
REACT_248642
Synthesis of substrates in N-glycan biosythesis pathway
REACT_262413
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_199008
Glycosphingolipid metabolism pathway
REACT_188937
Metabolism pathway
REACT_245163
Sphingolipid metabolism pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_202500
Sialic acid metabolism pathway
KEGG
mmu04614
Renin-angiotensin system pathway
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_111217
Metabolism pathway
REACT_204575
Glycosphingolipid metabolism pathway
REACT_223866
Asparagine N-linked glycosylation pathway
REACT_213782
Metabolism of proteins pathway
REACT_214405
Post-translational protein modification pathway
REACT_222556
Sphingolipid metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_213420
Sialic acid metabolism pathway
REACT_219139
Metabolism pathway
REACT_220681
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_226954
Synthesis of substrates in N-glycan biosythesis pathway
KEGG
hsa04614
Renin-angiotensin system pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 19025
UniGene Mm.359633
RefSeq NM_001038492 NM_008906
OMIM
CCDS CCDS17061 CCDS17062
HPRD
IMGT
MGI ID MGI:97748
MGI Symbol Ctsa
EMBL
GenPept
RNA Seq Atlas 19025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca