Version 5.4
Homo sapiens Gene: ART4
Summary
InnateDB Gene IDBG-21245.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ART4
Gene Name ADP-ribosyltransferase 4 (Dombrock blood group)
Synonyms ARTC4; CD297; DO; DOK1
Species Homo sapiens
Ensembl Gene ENSG00000111339
Encoded Proteins
IDBP-21247
ADP-ribosyltransferase 4 (Dombrock blood group)
IDBP-368146
ADP-ribosyltransferase 4 (Dombrock blood group)
IDBP-368152
ADP-ribosyltransferase 4 (Dombrock blood group)
IDBP-599181
ADP-ribosyltransferase 4 (Dombrock blood group)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14825569-14843495
Strand Reverse strand
Band p12.3
Transcripts
ENST00000228936 ENSP00000228936
ENST00000430129 ENSP00000412735
ENST00000420600 ENSP00000405689
ENST00000544616 ENSP00000442877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Biological Process
GO:0006471 protein ADP-ribosylation
GO:0006525 arginine metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030217
View Gene Order
ENSBTAG00000008352
Not yet available
Cross-References
SwissProt
TrEMBL Q3KZ29
UniProt Splice Variant
Entrez Gene 420
UniGene Hs.618457 Hs.655792
RefSeq NM_021071
HUGO HGNC:726
OMIM 110600
CCDS CCDS8668
HPRD 04364
IMGT
EMBL AC007655 AY829432
GenPept AAX39379
RNA Seq Atlas 420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca