Mus musculus Gene: Tnnt3 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Gene | IDBG-212580.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Tnnt3 | ||||||||||||||
Gene Name | troponin T3, skeletal, fast | ||||||||||||||
Synonyms | fTnT | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Gene | ENSMUSG00000061723 | ||||||||||||||
Encoded Proteins |
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
troponin T3, skeletal, fast
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Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130595:
The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009] |
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Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 7:142498836-142516009 | ||||||||||||||
Strand | Forward strand | ||||||||||||||
Band | F5 | ||||||||||||||
Transcripts | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Striated Muscle Contraction pathway
Muscle contraction pathway
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KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Striated Muscle Contraction pathway
Muscle contraction pathway
Muscle contraction pathway
Striated Muscle Contraction pathway
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KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Mm.389992 | ||||||||||||||
RefSeq | NM_001163664 NM_001163665 NM_001163666 NM_001163667 NM_001163668 NM_001163669 NM_001163670 NM_011620 XM_006508580 XM_006508582 XM_006508584 XM_006508585 XM_006508586 XM_006508587 XM_006508588 XM_006508589 XM_006508590 XM_006508591 XM_006508592 XM_006508593 XM_006508594 XM_006508595 XM_006508596 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS22031 CCDS52451 CCDS52452 CCDS52453 CCDS52454 CCDS52455 CCDS52456 CCDS52457 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||