InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc22a18

Summary

InnateDB Gene

IDBG-212738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc22a18

Gene Name

solute carrier family 22 (organic cation transporter), member 18

Synonyms

AW260131; BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2; p45-BWR1A; Slc22a1l; TSSC5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000000154

Encoded Proteins

IDBP-212740

solute carrier family 22 (organic cation transporter), member 18

IDBP-269857

solute carrier family 22 (organic cation transporter), member 18

IDBP-538482

solute carrier family 22 (organic cation transporter), member 18

IDBP-538871

solute carrier family 22 (organic cation transporter), member 18

IDBP-539209

solute carrier family 22 (organic cation transporter), member 18

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110628:
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms\' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Two alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:143473721-143499334

Strand

Forward strand

Band

Transcripts

ENSMUST00000052348	ENSMUSP00000056082
ENSMUST00000105917	ENSMUSP00000101537
ENSMUST00000146983
ENSMUST00000150791	ENSMUSP00000123047
ENSMUST00000145943	ENSMUSP00000115345
ENSMUST00000141988	ENSMUSP00000120434

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008514	organic anion transmembrane transporter activity
GO:0015238	drug transmembrane transporter activity
GO:0015293	symporter activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006820	anion transport
GO:0006855	drug transmembrane transport
GO:0015711	organic anion transport
GO:0015893	drug transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane