InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDX4

Summary

InnateDB Gene

IDBG-21276.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX4

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000152670

Encoded Proteins

IDBP-21278

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-21282

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-473928

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-473356

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-483533

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-479219

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-478942

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-482692

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-478477

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-479996

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-485405

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

IDBP-483016

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:55738017-55817157

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000354991	ENSP00000347087
ENST00000353507	ENSP00000334167
ENST00000505374	ENSP00000424838
ENST00000506511	ENSP00000427167
ENST00000508580
ENST00000515709	ENSP00000424779
ENST00000506848	ENSP00000421960
ENST00000514679	ENSP00000424112
ENST00000511491	ENSP00000427522
ENST00000503129	ENSP00000423102
ENST00000514278	ENSP00000425359
ENST00000511853	ENSP00000423123
ENST00000507645	ENSP00000430431
ENST00000509312

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007141	male meiosis I
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030317	sperm motility
GO:0032880	regulation of protein localization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0033391	chromatoid body
GO:0048471	perinuclear region of cytoplasm
GO:0071546	pi-body
GO:0071547	piP-body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021758

View Gene Order

ENSBTAG00000008871

Not yet available

Cross-References

SwissProt

TrEMBL

D6RIB2

UniProt Splice Variant

Entrez Gene

54514

UniGene

Hs.223581

RefSeq

NM_001142549 NM_001166533 NM_001166534 NM_024415 XM_005248545

HUGO

HGNC:18700

OMIM

605281

CCDS

CCDS3969 CCDS47208 CCDS54854 CCDS54855

HPRD

05593

IMGT

EMBL

AC016632

GenPept

RNA Seq Atlas

54514