Version 5.4
Homo sapiens Gene: MGP
Summary
InnateDB Gene IDBG-21291.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGP
Gene Name matrix Gla protein
Synonyms MGLAP; NTI
Species Homo sapiens
Ensembl Gene ENSG00000111341
Encoded Proteins
IDBP-21293
matrix Gla protein
IDBP-603548
matrix Gla protein
IDBP-595182
matrix Gla protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:14881181-14885926
Strand Reverse strand
Band p12.3
Transcripts
ENST00000228938 ENSP00000228938
ENST00000507170
ENST00000539261 ENSP00000445907
ENST00000545199 ENSP00000445436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0008147 structural constituent of bone
Biological Process
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0030154 cell differentiation
GO:0030500 regulation of bone mineralization
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000030218
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
fra_pathway
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000900 NM_001190839
HUGO
OMIM
CCDS CCDS53752 CCDS8669
HPRD 01112
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca