Mus musculus Gene: Nfatc2 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-213130.7 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | Nfatc2 | ||||||||||||||||||||||||||
Gene Name | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 | ||||||||||||||||||||||||||
Synonyms | AI607462; NF-ATc2; NF-ATp; NFAT1; NFAT1-D; Nfatp | ||||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000027544 | ||||||||||||||||||||||||||
Encoded Proteins |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||
Summary |
Nfatc2 is a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumorigenesis.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||
Summary |
[Homo sapiens] NFATC2 interacts with JUN to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
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Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101096:
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 2:168476410-168601657 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | H3 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Innate Immune System pathway
Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
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KEGG |
Axon guidance pathway
VEGF signaling pathway pathway
T cell receptor signaling pathway pathway
Wnt signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
B cell receptor signaling pathway pathway
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH |
KitReceptor pathway
Wnt pathway
TCR pathway
BCR pathway
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REACTOME |
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
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KEGG |
VEGF signaling pathway pathway
Wnt signaling pathway pathway
Axon guidance pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Noncanonical Wnt signaling pathway
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
UniGene | Mm.116802 Mm.415690 | ||||||||||||||||||||||||||
RefSeq | NM_001037177 NM_001037178 NM_001136073 NM_001291168 NM_001291169 NM_001291170 NM_001291171 NM_001291172 NM_001291173 NM_001291174 NM_001291175 NM_001291176 NM_001291177 NM_001291178 NM_001291179 NM_010899 XM_006498895 XM_006498896 | ||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | CCDS17112 CCDS17113 CCDS17114 CCDS50803 CCDS71201 | ||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||