Version 5.4
Mus musculus Gene: Prkca
Summary
InnateDB Gene IDBG-213736.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkca
Gene Name protein kinase C, alpha
Synonyms AI875142; Pkca
Species Mus musculus
Ensembl Gene ENSMUSG00000050965
Encoded Proteins
IDBP-213738
protein kinase C, alpha
IDBP-213740
protein kinase C, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19950169
[Homo sapiens] PRKCA is a key component that controls MyD88-dependent cytokine gene expression in human and mouse but differentially regulates production of TICAM1 (TRIF)-dependent cytokines.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154229:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:107933387-108343928
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000059595 ENSMUSP00000062392
ENSMUST00000100302 ENSMUSP00000097875
ENSMUST00000134910
ENSMUST00000134725
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 103 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019899 enzyme binding
GO:0035403 histone kinase activity (H3-T6 specific)
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002026 regulation of the force of heart contraction
GO:0002062 chondrocyte differentiation
GO:0002159 desmosome assembly
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006874 cellular calcium ion homeostasis
GO:0006937 regulation of muscle contraction
GO:0008285 negative regulation of cell proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035408 histone H3-T6 phosphorylation
GO:0035556 intracellular signal transduction
GO:0036289 peptidyl-serine autophosphorylation
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045931 positive regulation of mitotic cell cycle
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0050729 positive regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050930 induction of positive chemotaxis
GO:0070555 response to interleukin-1
GO:0071322 cellular response to carbohydrate stimulus
GO:0090330 regulation of platelet aggregation
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154229
View Gene Order
ENSBTAG00000001061
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04530
Tight junction pathway
mmu04012
ErbB signaling pathway pathway
mmu04370
VEGF signaling pathway pathway
mmu04020
Calcium signaling pathway pathway
mmu04916
Melanogenesis pathway
mmu04310
Wnt signaling pathway pathway
mmu04540
Gap junction pathway
mmu04664
Fc epsilon RI signaling pathway pathway
mmu04650
Natural killer cell mediated cytotoxicity pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu04912
GnRH signaling pathway pathway
mmu04010
MAPK signaling pathway pathway
mmu04720
Long-term potentiation pathway
mmu05214
Glioma pathway
mmu04150
mTOR signaling pathway pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04730
Long-term depression pathway
mmu05223
Non-small cell lung cancer pathway
mmu04510
Focal adhesion pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04270
Vascular smooth muscle contraction pathway
mmu05200
Pathways in cancer pathway
mmu04960
Aldosterone-regulated sodium reabsorption pathway
mmu05146
Amoebiasis pathway
mmu04971
Gastric acid secretion pathway
mmu04970
Salivary secretion pathway
mmu04972
Pancreatic secretion pathway
mmu05143
African trypanosomiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_15
IL3 pathway
NetPath_23
TSH pathway
NetPath_147
IL11 pathway
REACTOME
REACT_9000
Calmodulin induced events pathway
REACT_9053
CaM pathway pathway
REACT_111064
DAG and IP3 signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_1178
Disinhibition of SNARE formation pathway
REACT_1280
Response to elevated platelet cytosolic Ca2+ pathway
REACT_12079
PLC-gamma1 signalling pathway
REACT_12478
EGFR interacts with phospholipase C-gamma pathway
REACT_9417
Signaling by EGFR pathway
REACT_121096
EGFR Transactivation by Gastrin pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_15426
PLC beta mediated events pathway
REACT_15295
Opioid Signalling pathway
REACT_115720
PLCG1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21310
Phospholipase C-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111225
Regulation of KIT signaling pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_25218
HuR stabilizes mRNA pathway
REACT_18405
Acetylcholine regulates insulin secretion pathway
REACT_18325
Regulation of insulin secretion pathway
REACT_1505
Integration of energy metabolism pathway
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_172581
PCP/CE pathway pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_172761
Ca2+ pathway pathway
REACT_172599
WNT5A-dependent internalization of FZD4 pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_118779
Extracellular matrix organization pathway
REACT_11045
Signaling by Wnt pathway
REACT_13685
Neuronal System pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_163942
Syndecan interactions pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_15526
G-protein mediated events pathway
REACT_115566
Cell Cycle pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
REACT_910
M Phase pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_765
Mitotic Prophase pathway
REACT_160125
Visual phototransduction pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_163722
The phototransduction cascade pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_111217
Metabolism pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_200828
Depolymerisation of the Nuclear Lamina pathway
REACT_15307
Ca-dependent events pathway
REACT_71
Gene Expression pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04912
GnRH signaling pathway pathway
hsa05110
Vibrio cholerae infection pathway
hsa04370
VEGF signaling pathway pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa04540
Gap junction pathway
hsa05223
Non-small cell lung cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04012
ErbB signaling pathway pathway
hsa04010
MAPK signaling pathway pathway
hsa04720
Long-term potentiation pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05214
Glioma pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04510
Focal adhesion pathway
hsa04730
Long-term depression pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa04020
Calcium signaling pathway pathway
hsa04916
Melanogenesis pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa05200
Pathways in cancer pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04971
Gastric acid secretion pathway
hsa05146
Amoebiasis pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa05143
African trypanosomiasis pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
INOH website
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
cd8tcrpathway
TCR signaling in naïve CD8+ T cells
tcr_pathway
TCR signaling in naïve CD4+ T cells
cd8tcrdownstreampathway
Downstream signaling in naïve CD8+ T cells
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
mtor_4pathway
mTOR signaling pathway
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
atf2_pathway
ATF-2 transcription factor network
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
tcrraspathway
Ras signaling in the CD4+ TCR pathway
nfkappabcanonicalpathway
Canonical NF-kappaB pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
vegfr1_pathway
VEGFR1 specific signals
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.222178 Mm.408352 Mm.467877
RefSeq NM_011101
OMIM
CCDS CCDS25573
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca