Version 5.4
Mus musculus Gene: Hrh3
Summary
InnateDB Gene IDBG-213755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hrh3
Gene Name histamine receptor H3
Synonyms AW049250; H3R; HH3R
Species Mus musculus
Ensembl Gene ENSMUSG00000039059
Encoded Proteins
IDBP-213757
histamine receptor H3
IDBP-626178
histamine receptor H3
IDBP-626179
histamine receptor H3
IDBP-626181
histamine receptor H3
IDBP-626183
histamine receptor H3
IDBP-626185
histamine receptor H3
IDBP-626186
histamine receptor H3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101180:
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:180099465-180104488
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000056480 ENSMUSP00000049963
ENSMUST00000163215 ENSMUSP00000127053
ENSMUST00000165762 ENSMUSP00000132203
ENSMUST00000165248 ENSMUSP00000130181
ENSMUST00000166724 ENSMUSP00000126336
ENSMUST00000171736 ENSMUSP00000127085
ENSMUST00000164442 ENSMUSP00000130553
ENSMUST00000166392
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004969 histamine receptor activity
GO:0008144 drug binding
Biological Process
GO:0001505 regulation of neurotransmitter levels
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007420 brain development
GO:0007612 learning
GO:0007613 memory
GO:0014050 negative regulation of glutamate secretion
GO:0014053 negative regulation of gamma-aminobutyric acid secretion
GO:0014061 regulation of norepinephrine secretion
GO:0014063 negative regulation of serotonin secretion
GO:0014070 response to organic cyclic compound
GO:0042755 eating behavior
GO:0042756 drinking behavior
GO:0045776 negative regulation of blood pressure
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050890 cognition
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043209 myelin sheath
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101180
View Gene Order
ENSBTAG00000031625
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_252999
Amine ligand-binding receptors pathway
REACT_257161
Histamine receptors pathway
REACT_231468
GPCR ligand binding pathway
REACT_250376
G alpha (i) signalling events pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_16903
Histamine receptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q522
UniProt Splice Variant
Entrez Gene 99296
UniGene
RefSeq NM_133849
OMIM
CCDS CCDS17169
HPRD
IMGT
MGI ID MGI:2139279
MGI Symbol Hrh3
EMBL AL672130
GenPept
RNA Seq Atlas 99296

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca