Mus musculus Gene: Kcnq2
Summary
InnateDB Gene IDBG-213954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnq2
Gene Name potassium voltage-gated channel, subfamily Q, member 2
Synonyms HNSPC; KQT2; Nmf134;
Species Mus musculus
Ensembl Gene ENSMUSG00000016346
Encoded Proteins
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
potassium voltage-gated channel, subfamily Q, member 2
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075043:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181075579-181135291
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000016491 ENSMUSP00000016491
ENSMUST00000049792 ENSMUSP00000052453
ENSMUST00000103051 ENSMUSP00000099340
ENSMUST00000103050 ENSMUSP00000099339
ENSMUST00000081528 ENSMUSP00000080243
ENSMUST00000103049 ENSMUSP00000099338
ENSMUST00000103048 ENSMUSP00000099337
ENSMUST00000103047 ENSMUSP00000099336
ENSMUST00000149964 ENSMUSP00000122915
ENSMUST00000129695 ENSMUSP00000123488
ENSMUST00000145861
ENSMUST00000129073 ENSMUSP00000127061
ENSMUST00000152099
ENSMUST00000144592 ENSMUSP00000133237
ENSMUST00000139458 ENSMUSP00000130633
ENSMUST00000140789
ENSMUST00000154164 ENSMUSP00000131544
ENSMUST00000123336 ENSMUSP00000130700
ENSMUST00000129361 ENSMUSP00000131756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0030506 ankyrin binding
Biological Process
GO:0006811 ion transport
GO:0019226 transmission of nerve impulse
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0033268 node of Ranvier
GO:0043194 axon initial segment
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Potassium Channels pathway
Interaction between L1 and Ankyrins pathway
Axon guidance pathway
L1CAM interactions pathway
Neuronal System pathway
Developmental Biology pathway
Voltage gated Potassium channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Interaction between L1 and Ankyrins pathway
Neuronal System pathway
Axon guidance pathway
Voltage gated Potassium channels pathway
Potassium Channels pathway
L1CAM interactions pathway
KEGG
INOH
PID BIOCARTA
Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
Cross-References
SwissProt Q9Z351
TrEMBL B7ZBV3 B7ZBV4 B7ZBV5 B7ZBV6 B7ZBV7 B7ZBV8 B7ZBV9 B7ZBW1 B7ZBW2 E9PZW1 G3UWC1 G3XA60 G5E900
UniProt Splice Variant
Entrez Gene 16536
UniGene Mm.40615 Mm.409325 Mm.411074 Mm.411110 Mm.445614
RefSeq NM_001003824 NM_001003825 NM_001006668 NM_001006669 NM_001006674 NM_001006675 NM_001006676 NM_001006677 NM_001006678 NM_001006679 NM_001006680 NM_010611
OMIM
CCDS CCDS17193 CCDS17194 CCDS17195 CCDS17196 CCDS17197 CCDS17198 CCDS17199 CCDS17200 CCDS50845 CCDS50846 CCDS50847 CCDS50848
HPRD
IMGT
MGI ID MGI:1309503
MGI Symbol Kcnq2
EMBL AB000494 AB000495 AB000496 AB000497 AB000498 AB000499 AB000500 AB000501 AB000502 AB000503 AB000504 AF490773 AK139411 AL450341 BC145453 CH466626
GenPept AAI45454 AAM09696 BAA37156 BAA37157 BAA37158 BAA37159 BAA37160 BAA37161 BAA37162 BAA37163 BAA37164 BAA37165 BAA37166 BAE24000 EDL07375 EDL07376 EDL07377 EDL07378 EDL07379 EDL07381
ImmGen Kcnq2 (murine)
RNA Seq Atlas 16536