Mus musculus Gene: Kcnq2

Summary
InnateDB Gene IDBG-213954.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Kcnq2
Gene Name potassium voltage-gated channel, subfamily Q, member 2
Synonyms HNSPC; KQT2; Nmf134
Species Mus musculus
Ensembl Gene ENSMUSG00000016346
Encoded Proteins
IDBP-213956 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213958 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213960 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213962 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213964 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213966 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213968 potassium voltage-gated channel, subfamily Q, member 2
IDBP-213970 potassium voltage-gated channel, subfamily Q, member 2
IDBP-535762 potassium voltage-gated channel, subfamily Q, member 2
IDBP-539537 potassium voltage-gated channel, subfamily Q, member 2
IDBP-626628 potassium voltage-gated channel, subfamily Q, member 2
IDBP-626630 potassium voltage-gated channel, subfamily Q, member 2
IDBP-626635 potassium voltage-gated channel, subfamily Q, member 2
IDBP-626636 potassium voltage-gated channel, subfamily Q, member 2
IDBP-626637 potassium voltage-gated channel, subfamily Q, member 2
IDBP-626638 potassium voltage-gated channel, subfamily Q, member 2
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075043:
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2: 181075579-181135291
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000016491  ENSMUSP00000016491
ENSMUST00000049792  ENSMUSP00000052453
ENSMUST00000103051  ENSMUSP00000099340
ENSMUST00000103050  ENSMUSP00000099339
ENSMUST00000081528  ENSMUSP00000080243
ENSMUST00000103049  ENSMUSP00000099338
ENSMUST00000103048  ENSMUSP00000099337
ENSMUST00000103047  ENSMUSP00000099336
ENSMUST00000149964  ENSMUSP00000122915
ENSMUST00000129695  ENSMUSP00000123488
ENSMUST00000145861 
ENSMUST00000129073  ENSMUSP00000127061
ENSMUST00000152099 
ENSMUST00000144592  ENSMUSP00000133237
ENSMUST00000139458  ENSMUSP00000130633
ENSMUST00000140789 
ENSMUST00000154164  ENSMUSP00000131544
ENSMUST00000123336  ENSMUSP00000130700
ENSMUST00000129361  ENSMUSP00000131756
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein‑Protein  3
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 4 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0030506 ankyrin binding
Biological Process
GO:0006811 ion transport
GO:0019226 transmission of nerve impulse
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0033268 node of Ranvier
GO:0043194 axon initial segment
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000075043 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000003030 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
100055 Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
Cross-References
SwissProt Q9Z351 
TrEMBL B7ZBV3 B7ZBV4 B7ZBV5 B7ZBV6 B7ZBV7 B7ZBV8 B7ZBV9 B7ZBW0 B7ZBW1 B7ZBW2 E9PZW1 G3UWC1 G3XA60 G5E900
UniProt Splice Variant
Entrez Gene 16536 
UniGene Mm.40615 Mm.409325 Mm.411074 Mm.411110 Mm.445614
RefSeq NM_001003824  NM_001003825  NM_001006668  NM_001006669  NM_001006674  NM_001006675  NM_001006676  NM_001006677  NM_001006678  NM_001006679  NM_001006680  NM_010611 
OMIM
CCDS CCDS17193  CCDS17194  CCDS17195  CCDS17196  CCDS17197  CCDS17198  CCDS17199  CCDS17200  CCDS50845  CCDS50846  CCDS50847  CCDS50848 
HPRD
IMGT
MGI ID MGI:1309503 
MGI Symbol Kcnq2
EMBL AB000494 AB000495 AB000496 AB000497 AB000498 AB000499 AB000500 AB000501 AB000502 AB000503 AB000504 AF490773 AK139411 AL450341 BC145453 CH466626
GenPept AAI45454  AAM09696  BAA37156  BAA37157  BAA37158  BAA37159  BAA37160  BAA37161  BAA37162  BAA37163  BAA37164  BAA37165  BAA37166  BAE24000  CAX15856  CAX15857  CAX15858  CAX15859  CAX15860  CAX15861  CAX15862  CAX15863  CAX15864  CAX15865  EDL07375  EDL07376  EDL07377  EDL07378  EDL07379  EDL07381 
ImmGen Kcnq2 (murine) 
RNA Seq Atlas 16536