InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sumo2

Summary

InnateDB Gene

IDBG-214321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sumo2

Gene Name

SMT3 suppressor of mif two 3 homolog 2 (yeast)

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020738

Encoded Proteins

IDBP-214323

SMT3 suppressor of mif two 3 homolog 2 (yeast)

IDBP-400055

SMT3 suppressor of mif two 3 homolog 2 (yeast)

IDBP-400054

SMT3 suppressor of mif two 3 homolog 2 (yeast)

IDBP-400053

SMT3 suppressor of mif two 3 homolog 2 (yeast)

IDBP-542894

SMT3 suppressor of mif two 3 homolog 2 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188612:
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:115523102-115536276

Strand

Reverse strand

Band

Transcripts

ENSMUST00000050672
ENSMUST00000021084	ENSMUSP00000021084
ENSMUST00000118155	ENSMUSP00000113108
ENSMUST00000121185	ENSMUSP00000112594
ENSMUST00000117589	ENSMUSP00000113883
ENSMUST00000153892	ENSMUSP00000115044
ENSMUST00000140844

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1163 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1163 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0016925	protein sumoylation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter