Version 5.4
Mus musculus Gene: Unc13d
Summary
InnateDB Gene IDBG-214399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Unc13d
Gene Name unc-13 homolog D (C. elegans)
Synonyms 2610108D09Rik; Jinx; mFLJ00067; Munc13-4
Species Mus musculus
Ensembl Gene ENSMUSG00000057948
Encoded Proteins
IDBP-214401
unc-13 homolog D (C. elegans)
IDBP-268739
unc-13 homolog D (C. elegans)
IDBP-268741
unc-13 homolog D (C. elegans)
IDBP-541079
unc-13 homolog D (C. elegans)
IDBP-540540
unc-13 homolog D (C. elegans)
IDBP-622788
unc-13 homolog D (C. elegans)
IDBP-622791
unc-13 homolog D (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092929:
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:116062095-116077961
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000075036 ENSMUSP00000074549
ENSMUST00000106451 ENSMUSP00000102059
ENSMUST00000106450 ENSMUSP00000102058
ENSMUST00000155120
ENSMUST00000153408 ENSMUSP00000115327
ENSMUST00000156545 ENSMUSP00000118266
ENSMUST00000173345 ENSMUSP00000133679
ENSMUST00000174822 ENSMUSP00000134260
ENSMUST00000173943
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002432 granuloma formation
GO:0002467 germinal center formation
GO:0006909 phagocytosis
GO:0043304 regulation of mast cell degranulation
GO:0043320 natural killer cell degranulation
GO:0045921 positive regulation of exocytosis
GO:0051607 defense response to virus
Cellular Component
GO:0005764 lysosome
GO:0005770 late endosome
GO:0016020 membrane
GO:0055037 recycling endosome
GO:0070382 exocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000092929
View Gene Order
ENSBTAG00000013556
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.259460
RefSeq NM_001009573 XM_006534188 XM_006534189 XM_006534190 XM_006534191 XM_006534192
OMIM
CCDS CCDS25656
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca