Version 5.4
Homo sapiens Gene: TNFAIP2
Summary
InnateDB Gene IDBG-21447.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP2
Gene Name tumor necrosis factor, alpha-induced protein 2
Synonyms B94; EXOC3L3
Species Homo sapiens
Ensembl Gene ENSG00000185215
Encoded Proteins
IDBP-21449
tumor necrosis factor, alpha-induced protein 2
IDBP-592393
tumor necrosis factor, alpha-induced protein 2
IDBP-597298
tumor necrosis factor, alpha-induced protein 2
IDBP-585994
tumor necrosis factor, alpha-induced protein 2
IDBP-585262
tumor necrosis factor, alpha-induced protein 2
IDBP-587603
tumor necrosis factor, alpha-induced protein 2
IDBP-588636
tumor necrosis factor, alpha-induced protein 2
IDBP-589044
tumor necrosis factor, alpha-induced protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:103123442-103137439
Strand Forward strand
Band q32.32
Transcripts
ENST00000333007 ENSP00000332326
ENST00000559195
ENST00000558056 ENSP00000453103
ENST00000560869 ENSP00000452634
ENST00000560562 ENSP00000452824
ENST00000559406 ENSP00000452992
ENST00000560428
ENST00000560670 ENSP00000453142
ENST00000561156 ENSP00000453458
ENST00000559255 ENSP00000452914
ENST00000561217
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 7 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0006887 exocytosis
GO:0030154 cell differentiation
Cellular Component
GO:0000145 exocyst
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021281
View Gene Order
ENSBTAG00000035995
Not yet available
Cross-References
SwissProt
TrEMBL H0YL88
UniProt Splice Variant
Entrez Gene 7127
UniGene Hs.525607 Hs.660676 Hs.720660 Hs.732246
RefSeq NM_006291
HUGO HGNC:11895
OMIM 603300
CCDS CCDS9979
HPRD 04487
IMGT
EMBL AL161669
GenPept
RNA Seq Atlas 7127

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca