Version 5.4
| Mus musculus Gene: Socs3 | |||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-214604.6 | ||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
| Gene Symbol | Socs3 | ||||||||||||||||||||||||||||
| Gene Name | suppressor of cytokine signaling 3 | ||||||||||||||||||||||||||||
| Synonyms | Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3 | ||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000053113 | ||||||||||||||||||||||||||||
| Encoded Proteins |
suppressor of cytokine signaling 3
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| Protein Structure | |||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] SOCS3 inhibits the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis (EPO) by binding the JAK2 and EPO receptor, respectively.
[Homo sapiens] SOCS3 is rapidly induced by IL-2 in T cells where it acts to inhibit IL-2 responses in a classical negative feedback loop by suppressing STAT5 phosphorylation and lymphocyte proliferation.
[Homo sapiens] SOCS3 protein is a potent endogenous inhibitor of Janus kinase (JAK)/STAT signalling and influenza A virus inhibits type I IFN signalling via NF-kappaB-dependent induction of SOCS3 expression.
[Homo sapiens] SOCS3 is a molecular inhibitor of IFN signalling and SOCS3 expression, induced by stimuli present in the Human immunodeficiency virus (HIV)-1-infected brain, such as transactivator of transcription, inhibits antiviral IFN-beta signalling to enhance HIV-1 replication in macrophages, allowing HIV-1 to evade the protective innate immune response within the central nervous system.
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| Entrez Gene | |||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184557:
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||
| Genomic Location | Chromosome 11:117966079-117970047 | ||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||
| Band | E2 | ||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||
| REACTOME |
Mus musculus biological processes pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by Leptin pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Signaling by Interleukins pathway
Interleukin-6 signaling pathway
Adaptive Immune System pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
Signaling by Leptin pathway
Interferon alpha/beta signaling pathway
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| KEGG |
Ubiquitin mediated proteolysis pathway
Type II diabetes mellitus pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
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| INOH |
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
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| PID NCI | |||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||
| NETPATH |
EGFR1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
Leptin pathway
TSH pathway
Prolactin pathway
Oncostatin_M pathway
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| REACTOME |
Antigen processing: Ubiquitination & Proteasome degradation pathway
Growth hormone receptor signaling pathway
Regulation of IFNA signaling pathway
Interferon alpha/beta signaling pathway
Regulation of IFNG signaling pathway
Interferon gamma signaling pathway
Interleukin-6 signaling pathway
Cytokine Signaling in Immune system pathway
Signal Transduction pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by Interleukins pathway
Class I MHC mediated antigen processing & presentation pathway
Signaling by Leptin pathway
Regulation of IFNA signaling pathway
Signaling by Leptin pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Interferon gamma signaling pathway
Immune System pathway
Signal Transduction pathway
Interleukin-6 signaling pathway
Interferon Signaling pathway
Growth hormone receptor signaling pathway
Regulation of IFNG signaling pathway
Signaling by Interleukins pathway
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| KEGG |
Ubiquitin mediated proteolysis pathway
Insulin signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Adipocytokine signaling pathway pathway
Osteoclast differentiation pathway
Hepatitis C pathway
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| INOH |
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
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| PID NCI |
IL2-mediated signaling events
Signaling events mediated by PTP1B
ATF-2 transcription factor network
EPO signaling pathway
IL23-mediated signaling events
IL4-mediated signaling events
IL6-mediated signaling events
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| Cross-References | |||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||
| UniGene | Mm.3468 Mm.416149 | ||||||||||||||||||||||||||||
| RefSeq | NM_007707 XM_006532110 | ||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||
| CCDS | CCDS25697 | ||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||