InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hgs

Summary

InnateDB Gene

IDBG-214821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hgs

Gene Name

HGF-regulated tyrosine kinase substrate

Synonyms

Hgr; Hrs; ZFYVE8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025793

Encoded Proteins

IDBP-214823

HGF-regulated tyrosine kinase substrate

IDBP-269251

HGF-regulated tyrosine kinase substrate

IDBP-269253

HGF-regulated tyrosine kinase substrate

IDBP-532644

HGF-regulated tyrosine kinase substrate

IDBP-539059

HGF-regulated tyrosine kinase substrate

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185359:
The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120467635-120483984

Strand

Forward strand

Band

Transcripts

ENSMUST00000026900	ENSMUSP00000026900
ENSMUST00000106205	ENSMUSP00000101811
ENSMUST00000106203	ENSMUSP00000101809
ENSMUST00000141826
ENSMUST00000140862	ENSMUSP00000119396
ENSMUST00000135231	ENSMUSP00000115037

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	138 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0008333	endosome to lysosome transport
GO:0046426	negative regulation of JAK-STAT cascade

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030141	secretory granule
GO:0031901	early endosome membrane
GO:0032585	multivesicular body membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome