InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pycr1

Summary

InnateDB Gene

IDBG-214865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pycr1

Gene Name

pyrroline-5-carboxylate reductase 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025140

Encoded Proteins

IDBP-214867

pyrroline-5-carboxylate reductase 1

IDBP-540981

pyrroline-5-carboxylate reductase 1

IDBP-540979

pyrroline-5-carboxylate reductase 1

IDBP-534688

pyrroline-5-carboxylate reductase 1

IDBP-624312

pyrroline-5-carboxylate reductase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183010:
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:120635712-120643769

Strand

Reverse strand

Band

Transcripts

ENSMUST00000026133	ENSMUSP00000026133
ENSMUST00000141254	ENSMUSP00000114863
ENSMUST00000151876	ENSMUSP00000120558
ENSMUST00000139706	ENSMUSP00000117737
ENSMUST00000133908
ENSMUST00000170556	ENSMUSP00000131199

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004735	pyrroline-5-carboxylate reductase activity
GO:0005515	protein binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding
GO:0051287	NAD binding

Biological Process

GO:0006561	proline biosynthetic process
GO:0034599	cellular response to oxidative stress
GO:0046168	glycerol-3-phosphate catabolic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0055114	oxidation-reduction process
GO:0055129	L-proline biosynthetic process