Version 5.4
Homo sapiens Gene: RB1CC1
Summary
InnateDB Gene IDBG-21487.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RB1CC1
Gene Name RB1-inducible coiled-coil 1
Synonyms ATG17; CC1; FIP200; PPP1R131
Species Homo sapiens
Ensembl Gene ENSG00000023287
Encoded Proteins
IDBP-21489
RB1-inducible coiled-coil 1
IDBP-370577
RB1-inducible coiled-coil 1
IDBP-474071
RB1-inducible coiled-coil 1
IDBP-480670
RB1-inducible coiled-coil 1
IDBP-474311
RB1-inducible coiled-coil 1
IDBP-477302
RB1-inducible coiled-coil 1
IDBP-478961
RB1-inducible coiled-coil 1
IDBP-474360
RB1-inducible coiled-coil 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:52622456-52745843
Strand Reverse strand
Band q11.23
Transcripts
ENST00000025008 ENSP00000025008
ENST00000435644 ENSP00000396067
ENST00000521611
ENST00000519912 ENSP00000430809
ENST00000522957
ENST00000523594 ENSP00000430792
ENST00000518710 ENSP00000429879
ENST00000517963 ENSP00000429918
ENST00000518211 ENSP00000429115
ENST00000518468 ENSP00000429611
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 81 [view]
Protein-Protein 79 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0007254 JNK cascade
GO:0007507 heart development
GO:0010506 regulation of autophagy
GO:0043066 negative regulation of apoptotic process
GO:0045793 positive regulation of cell size
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031965 nuclear membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0070969 ULK1-ATG13-FIP200 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025907
View Gene Order
ENSBTAG00000000878
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL E5RH63
UniProt Splice Variant
Entrez Gene 9821
UniGene Hs.196102 Hs.702264
RefSeq NM_001083617 NM_014781 XM_006716491 XM_006716492 XM_006716493
HUGO HGNC:15574
OMIM 606837
CCDS CCDS34892 CCDS47856
HPRD 06019
IMGT
EMBL AC090814 AC113139
GenPept
RNA Seq Atlas 9821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca