Version 5.4
Mus musculus Gene: Dcxr
Summary
InnateDB Gene IDBG-214893.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcxr
Gene Name dicarbonyl L-xylulose reductase
Synonyms 0610038K04Rik; 1810027P18Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000039450
Encoded Proteins
IDBP-214895
dicarbonyl L-xylulose reductase
IDBP-269370
dicarbonyl L-xylulose reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169738:
The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:120725399-120727281
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000026144 ENSMUSP00000026144
ENSMUST00000106148 ENSMUSP00000101754
ENSMUST00000125242
ENSMUST00000122883
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
GO:0050038 L-xylulose reductase (NADP+) activity
GO:0050662 coenzyme binding
Biological Process
GO:0005997 xylulose metabolic process
GO:0006006 glucose metabolic process
GO:0006739 NADP metabolic process
GO:0008152 metabolic process
GO:0042732 D-xylose metabolic process
GO:0044237 cellular metabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005881 cytoplasmic microtubule
GO:0005902 microvillus
GO:0005903 brush border
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169738
View Gene Order
ENSBTAG00000008747
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00040
Pentose and glucuronate interconversions pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00040
Pentose and glucuronate interconversions pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.231091
RefSeq NM_026428 XM_006534029
OMIM
CCDS CCDS25755
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca